What can be done to help heal prurigo nodularis?

Prurigo Nodularis is a non-contagious skin disorder and very painful.

What can be done to help heal prurigo nodularis?
Drug Category: Immunologic agents -- These agents have immunomodulatory effects.





Drug Name


Thalidomide (Thalomid) -- Immunomodulatory agent that may suppress excessive production of TNF-alpha and may down-regulate selected cell surface adhesion molecules involved in leukocyte migration.


If %26lt;50 kg (110 lb), start at low end of dose regimen.





Adult Dose


100-300 mg/d with water, preferably hs and at least 1 h pc; may be combined with narrowband UV-B (TL-01) irradiation





Pediatric Dose


Not established





Contraindications


Documented hypersensitivity; pregnancy





Interactions


May increase sedation of alcohol, barbiturates, chlorpromazine, and reserpine; because of teratogenic effects, women must use 2 additional methods of contraception or abstain from intercourse





Pregnancy


X - Contraindicated in pregnancy





Precautions


Perform pregnancy test within 24-h period prior to initiating therapy (weekly during the first mo, followed by monthly tests in women with regular menstrual cycles or q2wk in women with irregular menstrual cycles); bradycardia may occur; use protective measures (eg, sunscreens, protective clothing) against exposure to sunlight or UV light (eg, tanning beds)
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